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pentobarbital will minimize the level or result of pitolisant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Pitolisant exposure is reduced by fifty% if coadministered with potent CYP3A4 inducers.pentobarbital will reduce the extent or result of cobimetinib by affecting hepatic/intestinal enzyme CYP3A4 meta